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Synlett 1993; 1993(9): 677-679
DOI: 10.1055/s-1993-22569
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Stereocontrolled Synthesis of 2′-α-C-Branched Nucleoside Analogues and their Incorporation into Oligodeoxyribonucleotides

Alain De Mesmaeker* , Jacques Lebreton, Pascale Hoffmann, Susan M. Freier
  • *Central Research Laboratories, CIBA-GEIGY Ltd., CH-4002 Basel, Switzerland
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Publication Date:
19 March 2002 (online)

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The stereoselective synthesis of 2′-α-C-branched nucleosides by a radical addition reaction is described. These new nucleosides were incorporated into oligodeoxyribonucleotides. Measurement of melting temperatures (Tm) of DNA/RNA duplexes and the nuclease resistance of these oligoribodeoxynucleotides are presented.

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