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Synlett 1993; 1993(7): 463-465
DOI: 10.1055/s-1993-22491
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Synthesis of Cleviolide and the Scobinolides

Gregory J. Hollingworth* , J. B. Sweeney
  • *School of Chemistry, University of Bristol, Cantocks Close, Bristol BS8 1TS, England
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Publication History

Publication Date:
19 March 2002 (online)

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The polyunsaturated 2(5H)-furanone natural products cleviolide (1) and (E)- and (Z)-scobinolide (2) and (3) have been efficiently synthesized in convergent fashion via palladiumcatalyzed coupling of 4-tributylstannyl-2(5H)-furanone (4) and 1-iodo-4-methylpent-3-en-1-yne (5).

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