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Synlett 1993; 1993(6): 431-433
DOI: 10.1055/s-1993-22484
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Bischler-Napieralski Reaction of C2′, Functionalized 1,2-Diarylethylamides: A General Approach to the Synthesis of Protoberberines

N. Sotomayor* , E. Domínguez, E. Lete
  • *Departamento de Química Orgánica, Facultad de Ciencias, Universidad del País Vasco, Apdo. 644, E-48080 Bilbao, Spain
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Publication Date:
19 March 2002 (online)

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A synthetic route towards the protoberberines is reported. The key transformations are derived from the intramolecular cyclization of C2′, functionalized 1,2-diarylethylamides under. Bischler-Napieralski reaction conditions. This procedure afforded the quinolizidine nucleus of these alkaloids in one-pot.