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Synlett 1993; 1993(5): 365-366
DOI: 10.1055/s-1993-22459
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The Palladium Catalyzed Coupling of β-Trifuoromethanesulfonyl α,β-Unsaturated Esters and Ketones with β-Stannyl Enoates: Synthesis of Electron Deficient Dienes

Ioannis N. Houpis* , Lisa DiMichele, Audrey Molina
  • *Merck Research Laboratories, Department of Process Research, P.O.Box 2000, RY 801-205, Rahway, New Jersey 07065, USA
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Publication History

Publication Date:
19 March 2002 (online)

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The synthesis of electron deficient dienes has been accomplished by the palladium catalyzed coupling of β-stannyl-α,β-unsaturated esters with β-trifluoro-methanesulfonyl-α,β-unsaturated esters and ketones and is efficient only in tetrahydrofuran and a palladium to phosphine ratio of 1:2.