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Synlett 1993; 1993(5): 357-358
DOI: 10.1055/s-1993-22455
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Synthesis of Lysergic Acid Derivatives by Tandem Radical Cyclisation Reactions

Y. Ozlu* , D. E. Cladingboel, P. J. Parsons
  • *Department of Chemistry, University of Reading, Whiteknights, P.O.Box 224, Reading, RG6 2AD, England
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Publication Date:
19 March 2002 (online)

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A double radical cyclisation of a 2-bromoaniline derivative, initiated with tri-n-butyltin hydride, to construct the lysergic acid ring system is described; formation of a 6-membered D ring is controlled by an intramolecular thermal cyclisation prior to radical addition.

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