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Synlett 1993; 1993(5): 349-350
DOI: 10.1055/s-1993-22451
DOI: 10.1055/s-1993-22451
letter
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Aza-Cope/Mannich Tandem Reaction Applied to the Asymmetric Synthesis of a Homochiral Proline Derivative
Further Information
Publication History
Publication Date:
19 March 2002 (online)
The synthesis of a homochiral 4-substituted proline derivative was achieved via a reaction sequence whose key-step was a cationic aza-Cope rearrangement/Mannich cyclization. This tandem reaction allowed a stereoselective creation of two stereogenic centers.