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Synlett 1993; 1993(5): 339-341
DOI: 10.1055/s-1993-22447
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An Enzymatic Entry to Enantiopure ß-Amino Acids

Vadim A. Soloshonok* , Vytas K. Svedas, Valery P. Kukhar, Alexander G. Kirilenko, Antonina V. Rybakova, Vladimir A. Solodenko, Nataly A. Fokina, Oleg V. Kogut, Igor Yu. Galaev, Elena V. Kozlova, Iren P. Shishkina, Sergey V. Galushko
  • *Institute of Bioorganic and Petrol Chemistry of Ukrainian Academy of Sciences, 253160 Kiev, Ukraine
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Publication Date:
19 March 2002 (online)

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A biocatalytic method of preparation of optically pure (>99% e.e.) enantiomers of fluorine-containing and fluorine-free ß-amino acids by means of penicillin acylase-catalyzed resolution of their racemic N-phenylacetyl derivatives has been developed.