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Synlett 1993; 1993(5): 313-322
DOI: 10.1055/s-1993-22442
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Synthetic Modifications of Biologically Interesting Natural Products

Albert T. Sneden*
  • *Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284-2006, USA
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Publication Date:
19 March 2002 (online)

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The role of synthesis in a research program primarily devoted to the isolation, structure elucidation, and development of biologically active natural products is often to aid in the structure elucidation, provide homologues for examination of structure-activity relationships, and to prepare analogues with modified activity. Examples of each activity are presented from work on the maytansinoids and steganins. Another consequence of some of the natural products studies have been short syntheses of ancepsenolide and natural products containing a 1,3,3-trimethyl-7-oxabicycl[2.2.1]heptane nucleus. 1. Introduction 2. Semi-Synthetic Modifications of Natural Products 3. Syntheses of "Small" Natural Products 4. Conclusion