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Synlett 1993; 1993(4): 295-296
DOI: 10.1055/s-1993-22438
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Asymmetric Synthesis of (S)-Vigabatrin. An Approach Using Methionine as the Chiral Pool

Zhong-Yong Wei* , Edward E. Knaus
  • *Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
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Publication Date:
19 March 2002 (online)

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An efficient methodology for the enantioselective synthesis of (S)-γ-vinyl GABA was developed. The target chiral compound was prepared starting from commercially available (R)-methionine in five steps in 27% overall yield.

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