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Synlett 1993; 1993(3): 195-196
DOI: 10.1055/s-1993-22398
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Mild and Selective Debenzylation of Tertiary Amines Using α-Chloroethyl Chloroformate

Bingwei V. Yang* , Dawn O'Rourke, Jiancheng Li
  • *Department of Medicinal Chemistry, Central Research Division, Pfizer Inc., Groton, Connecticut 06340, USA
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Publication History

Publication Date:
19 March 2002 (online)

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A mild and efficient procedure is described for the N-debenzylation of tertiary amines using α-chloroethyl chloroformate. The scope and selectivity are also discussed.