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Synlett 1993; 1993(3): 186-188
DOI: 10.1055/s-1993-22394
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The Reaction of Fluorovinyl Ketones with Carbon Nucleophiles: A New General Route to α,β-Unsaturated Ketones

Junji Ichikawa* , Naoyuki Yokota, Masakuni Kobayashi, Toru Minami
  • *Department of Applied Chemistry, Kyushu Institute of Technology, Sensui-cho, Tobata, Kitakyushu 804, Japan
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Publication Date:
19 March 2002 (online)

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2,2-Difluorovinyl ketones are quite reactive toward carbon nucleophiles such as copper and magnesium reagents, of which reaction causes the stepwise substitution of two fluorine atoms with different groups via conjugate addition-elimination process to afford fully substituted α,β-unsaturated ketones in good yields.

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