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Synlett 1993; 1993(2): 139-140
DOI: 10.1055/s-1993-22379
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Chiral Template Approach to 1,2-Disubstituted Carbacephem Antibiotics: Highly Chemoselective Reactions of Bicyclic Lactam Intermediates Bearing Multi-Carbonyl Functions with Nucleophiles

Seiki Saito* , Teruhiko Ishikawa, Toshio Moriwake
  • *Department of Applied Chemistry, Faculty of Engineering, Okayama University, 3-1-1 Tsushima-naka, Okayama 700, Japan
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Publication Date:
19 March 2002 (online)

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Diazabicyclio[4.2.0]-system consisted of N-(p-methoxyphenyl)-β-lactam and N′-Boc-δ-lactam subunits undergoes highly chemoselective reaction with various carbon nucleophiles at the carbonyl group of the δ-lactam-ring to give substituted β-lactam derivatives as precursors required for 1,2-disubstituted carbacephem antibiotics.