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Synthesis 1992; 1992(11): 1099-1103
DOI: 10.1055/s-1992-26314
DOI: 10.1055/s-1992-26314
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
First Synthetic Access to 6-(Methylene)oxapenems: A New Class of ß-Lactamase Inhibitors
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Publikationsverlauf
Publikationsdatum:
17. September 2002 (online)
![](https://www.thieme-connect.de/media/synthesis/199211/lookinside/thumbnails/10.1055-s-1992-26314-1.jpg)
The first synthetic route to racemic 6-(substituted methylene)oxapenems, an interesting new class of ß-lactamase inhibitors, is described. In spite of their low hydrolytic stability, even the unprotected acids 9 and 10 can be isolated as their sodium salts. The 6-(unsubstituted methylene)oxapenem 7e, however, is unstable and decomposes under the conditions of its formation.