Synthesis 1992; 1992(11): 1065-1067
DOI: 10.1055/s-1992-26301
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Convenient Synthesis of (±)-2-Carboxy-4-(3-phosphonopropyl)piperazine (CPP)

Derek A. Demaine* , Steven Smith, Paul Barraclough
  • *Department of Medicinal Chemistry, Wellcome Research Laboratories, Langley Court, South Eden Park Road, Beckenham, Kent, BR3 3BS, England
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
17. September 2002 (online)

A short and convenient route to the N-methyl-D-aspartate (NMDA) antagonist 2-carboxy-4-(3-phosphonopropyl)piperazine (CPP), involving selective N-4 alkylation of piperazine-2-carboxylic acid esters, is described. The method uses readily available starting materials and is suitable for multigram quantities.