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Synthesis 1992; 1992(11): 1065-1067
DOI: 10.1055/s-1992-26301
short paper
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A Convenient Synthesis of (±)-2-Carboxy-4-(3-phosphonopropyl)piperazine (CPP)

Derek A. Demaine* , Steven Smith, Paul Barraclough
  • *Department of Medicinal Chemistry, Wellcome Research Laboratories, Langley Court, South Eden Park Road, Beckenham, Kent, BR3 3BS, England
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Publication Date:
17 September 2002 (online)

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A short and convenient route to the N-methyl-D-aspartate (NMDA) antagonist 2-carboxy-4-(3-phosphonopropyl)piperazine (CPP), involving selective N-4 alkylation of piperazine-2-carboxylic acid esters, is described. The method uses readily available starting materials and is suitable for multigram quantities.