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Synthesis 1992; 1992(9): 837-838
DOI: 10.1055/s-1992-26240
short paper
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Vereinfachte Peptidsynthese mit schutzgruppenfreien Aminosäure-Hydrochloriden nach dem Prinzip der Vierkomponenten-Kondensation

Jürgen Kintscher* , Jürgen Martens
  • *Fachbereich Chemie, Universität Oldenburg, Postfach 2503, D-2900 Oldenburg i. O., Germany
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Publication Date:
17 September 2002 (online)

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Simplified Synthesis of Peptides with Non-protected Amino acid hydrochlorides via Four-Component Condensation Synthesis of sulfur containing peptide analogues, 3-(ω-aminoalkanoyl)-2, 2-dimethyl-1,3-thiazolidine-4-carboxamides 2, via Ugi four-component condensation (4CC) starting from 2,5-dihydro-1,3-thiazoles 1, isocyanides and non-protected amino acid hydrochlorides is described. Involvement of N-phthaloyl amino acids in a typical 4CC and following dephthaloylation of the resulting compounds 2,2-dimethyl-3-(ω-phthalimidoalkanoyl)-1, 3-thiazolidine-4-carboxamides 3, affords peptides 2 in lower overall yields than by the one-step way.