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Synthesis 1992; 1992(7): 701-704
DOI: 10.1055/s-1992-26204
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Synthesis of New Bicyclic Oxazaphosphorine Analogues: 2-[Bis(2-chloroethyl)amino]-2-oxo-3-oxa-7-thia-1-aza-2-phosphabicyclo[4.4.0]decane and -[4.3.0]nonane

Brigitte F. Schmidt* , Wei-Ci Tang, Gerhard Eisenbrand
  • *Fachrichtung Lebensmittelchemie and Umwelttoxikologie, Fachbereich Chemie, Universität Kaiserslautern, Erwin Schrödingerstr., D-6750 Kaiserslautern, Germany
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Publication Date:
17 September 2002 (online)

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The synthesis of two new bicyclic structures 2-[bis(2-chloroethyl)-amino]-2-oxo-3-oxa-7-thia-1-aza-2-phosphabicyclo[4.4.0]decane (12) and -[4.3.0]nonane (13) is described. These compounds were made in the search for potential antitumor agents with reduced toxicity.