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Synthesis 1992; 1992(7): 605-617
DOI: 10.1055/s-1992-26174
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Practical and Useful Methods for the Enantioselective Reduction of Unsymmetrical Ketones

Vinod K. Singh*
  • *Department of Chemistry, Indian Institute of Technology, Kanpur-208016, India
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Publication History

Publication Date:
17 September 2002 (online)

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Enantioselective reduction of unsymmetrical ketones to optically active alcohols is very important in organic synthesis. Catalytic methods have been developed for this process and have not been reviewed previously. In this article the recently developed oxazaborolidine catalyzed reduction along with other useful reagents will be discussed. 1. Introduction 2. Oxazaborolidines 3. B-3-pinanyl-9-borabicyclo[3.3.1]nonane 4. Chlorodiisopinocampheylborane 5. 2,5-Dimethylborolane 6. BINAL-H 7. BINAP-Ru Complex 8. Conclusion