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Synthesis 1992; 1992(6): 552-554
DOI: 10.1055/s-1992-26163
short paper
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Palladium-Catalyzed Cross-Coupling Reaction of Haloazoles with Phenylsulfonylacetonitrile

Takao Sakamoto* , Yoshinori Kondo, Takashi Suginome, Setsuya Ohba, Hiroshi Yamanaka
  • *Pharmaceutical Institute, Tohoku University, Aobayama, Aoba-ku, Sendai 980, Japan
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Publication Date:
17 September 2002 (online)

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Condensation of halo-substituted 1,3-azoles (1,3-oxazoles, 1,3-thiazoles and imidazoles) with phenylsulfonylacetonitrile under basic conditions was promoted by catalytic action of tetrakis(triphenylphosphine)palladium(0) to give α-phenylsulfonyl-1,3-azoleacetonitriles. The adaptability of halogen atoms for the cross-coupling reaction was investigated. The reaction of 4-halo-1,2-azoles was also examined.