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Synthesis 1992; 1992(6): 528-530
DOI: 10.1055/s-1992-26153
short paper
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The Synthesis of Thienopyridines from ortho-Halogenated Pyridine Derivatives

D. H. Bremner* , A. D. Dunn, K. A. Wilson
  • *Dundee Institute of Technology, Department of Molecular and Life Sciences, Bell Street, Dundee DD1 1HG, Scotland
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Publication Date:
17 September 2002 (online)

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The synthesis of 2- and 4-chloro-3-cyanomethylpyridine, 3-bromo-2-cyanomethylpyridine and 3-bromo-4-cyanomethylpyridine containing methylene groups activated by the nitrile functionality is reported. Reaction of these compounds with sodium hydride and carbon disulfide, followed by iodomethane gives the corresponding thienopyridines.

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