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Synthesis 1992; 1992(5): 491-494
DOI: 10.1055/s-1992-26144
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The Use of Formamidine Acetate in the Traube Synthesis of 9-Glycosylpurines

M. Melguizo* , M. Nogueras, A. Sánchez
  • *Departamento de Química Orgánica, Facultad de Ciencias Experimentales de Jaén, E-23071, Jaén, Spain
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Publikationsdatum:
17. September 2002 (online)

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Several 9-glycopyranosylpurin-6(1H)-one derivatives, where the glycosyl moiety was xylopyranosyl, glucopyranosyl 2,3,4,6-tetra-O-acetylglycopyranosyl, or 2,3,4-tri-O-xylopyranosyl, were obtained by reaction of formamidine acetate with 5-amino-6-(glycopyranosylamino)pyrimidin-4(3H)-ones or 5-amino-6-{[(per-O-acetyl)glycopyranosyl]amino}pyrimidin-4(3H)-ones, respectively. The reaction conditions were mild, such that good yields, around 60%, were obtained.