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Synthesis 1992; 1992(4): 409-412
DOI: 10.1055/s-1992-26124
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Radical Addition of 2,2,2-Trifluoroethyl Iodide to Terminal Alkenes

R. Cloux* , Sz. E. Kováts
  • *Laboratoire de Chimie -Technique de l'Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland
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Publikationsdatum:
17. September 2002 (online)

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2,2,2-Trifluoroethyl iodide adds to terminal alkenes under free radical conditions in good yields if the radical initiator is added in successive portions to the reaction mixture. Reduction of the resulting secondary iodides with sodium borohydride gives the corresponding trifluoroethyI-substituted products in overall yields of 40-60%. The reaction seems to be restricted to vinyl double bonds