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Synthesis 1992; 1992(3): 328-332
DOI: 10.1055/s-1992-26102
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An Efficient Synthesis of Symmetric Bilindiones. Mesobilirubin-Xlllα and Analogs with Varying Alkanoic Acid Chain Lengths

David P. Shrout* , Gisbert Puzicha, David A. Lightner
  • * Department of Chemistry, University of Nevada, Reno, Nevada 89557-0020, USA
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Publication Date:
17 September 2002 (online)

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An inexpensive gram-scale, three-step procedure is described to convert methyl xanthobilirubinate and it alkanoic acid ester analogs (methyl 5-[(3-ethyl-1, 5-dihydro-4-methyl-5-oxo-2H-pyrrol-2-ylidene)methyl]-1, 4-dimethylpyrrol-3-ethanoate, -propanoate, -butanoate, -pentanoate, -hexanoate) into mesobilirubin-XIIIα and analogs in > 90% yield at each step.