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Synthesis 1992; 1992(3): 248-257
DOI: 10.1055/s-1992-26080
review
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Addition of Organochromium Compounds to Aldehydes: The Nozaki-Hiyama Reaction

Pedro Cintas*
  • *Department of Organic Chemistry, Faculty of Sciences, University of Extremadura, E-06071 Badajoz, Spain
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Publication History

Publication Date:
17 September 2002 (online)

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This review examines the chromium(II)-mediated coupling reaction of carbonyl compounds with unsaturated substrates. The so-called Nozaki-Hiyama reaction has become an useful and versatile tool in organic synthesis. Applications to several natural product syntheses have also demonstrated its effectiveness. 1. Introduction 2. The Reagent. Some Considerations 3. Coupling of Alkyl Halides 4. Synthesis of Allylic and Homoallylic Alcohols 5. Olefination of Aldehydes 6. Miscellaneous Reactions 7. Applications to Natural Product Syntheses