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Synthesis 1991; 1991(7): 531-532
DOI: 10.1055/s-1991-26509
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A New Synthesis of Progesterone from 17-[Isocyano(tosyl)methylene]-3-methoxyandrosta-3,5-diene

Daan van Leusen* , Albert M. van Leusen
  • *Department of Organic Chemistry, Groningen University, Nijenborgh 16, NL-9747 AG, The Netherlands
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Publication Date:
29 April 2002 (online)

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Progesterone (4) is synthesized in 93% overall yield in three steps from 17-[(E)-isocyano(tosyl)methylene]-3-methoxyandrosta-3,5-diene (1).