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Synthesis 1991; 1991(5): 409-413
DOI: 10.1055/s-1991-26480
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Total Synthesis of the Biphenomycins; II.1 Synthesis of Protected (2S,4R)-4-Hydroxyornithines

Ulrich Schmidt* , Regina Meyer, Volker Leitenberger, Florian Stäbler, Albrecht Lieberknecht
  • *Institut für Organische Chemie und Isotopenforschung der Universität Stuttgart, Pfaffenwaldring 55, D-7000 Stuttgart 80, Germany
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Publication Date:
29 April 2002 (online)

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Improved synthetic methods for the preparation of three differently protected (2S,4R)-4-hydroxyornithines (10, 16, 24) have been developed which obviously can be used for the construction of the other stereoisomers. Formation of the corresponding α, β-didehydroamino acid derivatives (4, 15, 22) and their enantioselective hydrogenation are the characteristic steps of these syntheses.