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Synthesis 1991; 1991(4): 303-306
DOI: 10.1055/s-1991-26450
DOI: 10.1055/s-1991-26450
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Polycyclic N-Hetero Compounds; XXXIX: A Facile Synthesis of 1,2,4,5-Tetrahydro-[1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidines via Ring Closure of 4-(2-Hydroxyalkylamino)-5,6-dihydro-[1]benzoxepino[5,4-d]pyrimidines
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Publikationsdatum:
29. April 2002 (online)
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The first example of the unknown [1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidine ring system is demonstrated as a new class of potent anit-platelet aggregation agents. That is, the 1,2,4,5-tetrahydro-[1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidines 11a-c were prepared by ring closure of 4-(2-hydroxyalkylamino)-5,6-dihydro-[1]benzoxepino[5,4-d]pyrimidines 10a-c with phosphoryl chloride.