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Synthesis 1991; 1991(3): 211-213
DOI: 10.1055/s-1991-26422
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A Convenient Synthesis of 8-Alkyl- and 8-Alkylthio-2-(4-pyridyl)adenines

Balder Singh* , George Y. Lesher
  • *Department of Medicinal Chemistry, Sterling Research Group, Rensselaer, NY 12144, USA
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Publication Date:
17 September 2002 (online)

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Several 8-alkyl-2-(4-pyridyl)adenine analogs 5 were prepared by reacting 4,5,6-triaminopyrimidine 4 with acid anhydrides, acids or dimethylformamide dimethyl acetal. 8-Mercapto-2-(4-pyridyl)-adenine (6), prepared by treating 4 with O-potassium O-ethyl dithiocarbonate was alkylated to give 8-alkylthioadenine derivatives 7.

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