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Synthesis 1991; 1991(3): 207-209
DOI: 10.1055/s-1991-26420
DOI: 10.1055/s-1991-26420
paper
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4-Ethoxy-1,1,1-trifluoro-3-buten-2-one as a New Protecting Reagent in Peptide Synthesis
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Publikationsverlauf
Publikationsdatum:
17. September 2002 (online)
![](https://www.thieme-connect.de/media/synthesis/199103/lookinside/thumbnails/10.1055-s-1991-26420-1.jpg)
The 4,4,4-trifluoro-3-oxo-1-butenyl group is proposed as a suitable protecting group for the protection of the N-H terminal of amino acids in peptide synthesis. Amino acids react with 4-ethoxy-1,1,1-trifluoro-3-buten-2-one to give the N-protected amino acids, the protecting group can be removed by acidic hydrolysis. The formation of peptide bonds using on N-4,4,4-trifluoro-3-oxo-1-butenyl protected amino acids occurs without racemization.