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Synthesis 1991; 1991(1): 41-42
DOI: 10.1055/s-1991-26375
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A Facile Synthesis of 1,6-Naphthyridin-5(6H)-ones

Nagatoshi Nishiwaki* , Mitsuo Komatsu, Yoshiki Ohshiro
  • *Department of Applied Chemistry, Faculty of Engineering, Osaka University, Yamadaoka 2-1, Suita, Osaka 565, Japan
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Publikationsdatum:
17. September 2002 (online)

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3-Cyano-2-(phenylethynyl)pyridine (1) was cyclized intramolecularly under acidic conditions to give 1,6-naphthyridin-5(6H)-one (2) and 5H-pyrano[4,3-b]pyridin-5-one (4). Pyranopyridine 4 was readily transformed to 2 or naphthyridinone 9 having an alkyl substituent at 6-position.