Synlett 1991; 1991(11): 825-826
DOI: 10.1055/s-1991-20892
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Chemoselective Conjugate Reduction of α,β-Unsaturated Esters and Lactones Under Mild Conditions

J. Cristóbal López* , Ana M. Gómez, Serafín Valverde
  • *Instituto de Química Orgánica General, C.S.I.C., Juan de la Cierva 3, E-28006 Madrid, Spain
Further Information

Publication History

Publication Date:
07 March 2002 (online)

Several pyranose-derived α,β-unsaturated lactones and esters undergo chemoselective conjugate reduction by a tandem benzenethiol addition-tributyltin hydride reduction, without isolation of the intermediates, to the corresponding carbonyl compounds in good yield. The method is compatible with the presence of various protecting groups.