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Synlett 1991; 1991(11): 821-823
DOI: 10.1055/s-1991-20890
DOI: 10.1055/s-1991-20890
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Reduction of the Pyrimidine Ring: Regio- and Stereoselective Synthesis of 1,3-Diamine Derivatives
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Publikationsverlauf
Publikationsdatum:
07. März 2002 (online)
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1-Butyl-1,2-dihydropyrimidines 2 and 6,7,8,8a-tetrahydropyrrolo[1,2-a]pyrimidines 3 are reduced with an excess of sodium borohydride in methanol to produce stereoselectively N,N′ - and N,N-disubstituted 1,3-diamine derivatives 4 and 6, respectively. Partial reduction of 3 to fully saturated pyrrolo[1,2-a]pyrimidines 7 is accomplished using equimolecular amounts of sodium borohydride.