Synlett 1991; 1991(11): 803-804
DOI: 10.1055/s-1991-20882
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Preparation of tert-Butyl 4-N-(ω-Aminoalkyl)aminobenzoates by Nucleophilic Aromatic Substitution

S. Barret Kalindjian* , Richard A. G. Smith
  • *SmithKline Beecham Pharmaceuticals, Great Burgh, Yew Tree Bottom Road, Epsom, Surrey KT18 5XQ, England
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
07. März 2002 (online)

Nucleophilic aromatic substitution of tert-butyl 4-fluorobenzoate (3) with α,ω-diamines 5 has been used to provide the synthetic intermediates 2 [tert-butyl 4-N-(ω-aminoalkyl)amino-benzoates] in good yields.