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Synthesis 1990; 1990(10): 915-917
DOI: 10.1055/s-1990-27052
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A Directed Metalation Approach to 2-Trialkylammoniomethyl-3-trimethylsilylmethyl)-thiophene Iodides: Precursors to 2,3-Bis(methylene)-2,3-dihydrothiophene

Andrew Plant* , Derek J. Chadwick
  • *The Robert Robinson Laboratories, Department of Organic Chemistry, The University of Liverpool, P.O. Box 147, Liverpool, L69 3BX, England
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Publication Date:
17 September 2002 (online)

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Syntheses of precursors to 2,3-bis(methylene)-2,3-dihydrothiophene (2) are described. As key step, a lithiation reaction using secondary carboxamido functionality as directing group is used.