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Synthesis 1990; 1990(8): 651-653
DOI: 10.1055/s-1990-26969
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Synthesis of 3′-Deoxy-2′,3′-didehydro-3′-methylthymidine. A Potential Anti-HIV Agent

Stanislas Czernecki* , Abdallah Ezzitouni, Pierre Krausz
  • *Laboratoire de Chimie des Glucides, Université Pierre et Marie Curie, T74, E6, 4 Place Jussieu, F-75005 Paris, France
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Publication Date:
17 September 2002 (online)

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Starting from 1,2-O-isopropylidene-α-D-xylofuranose, a versatile method for the synthesis of branched 3′-deoxy-2′,3′-didehydro nucleosides is described and exemplified for an analogue of 3′-deoxy-2′,3′-didehydrothymidine (d4T).