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Synthesis 1990; 1990(6): 457-458
DOI: 10.1055/s-1990-26902
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Short and Efficient Synthesis of Statine and Isostatine Derivatives

Horst Kessler* , Manfred Schudok
  • *Organisch-chemisches Institut, Technische Universität München, Lichtenbergstraße 4, D-8046 Garching; Federal Republic of Germany
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Publication Date:
17 September 2002 (online)

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The preparation of Fmoc-(3R,4S)-statine tert-butyl ester [tert-butyl (3R,4S)-4-(9-fluorenylmethoxycarbonylamino) -3-hydroxy-6-methylheptanoate] and the corresponding (3S,4R,5S)-isostatine derivative from Fmoc-leucine and Fmoc-D-alloisoleucine respectively by sequential activation, ß-keto ester formation and reduction, is described.