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Synthesis 1990; 1990(5): 425-427
DOI: 10.1055/s-1990-26895
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A Facile and Convenient Synthetic Route to 1-Amino-4,4-bis(trifluoroacetyl)- and 1-Amino-4-trifluoroacetyl-1,3-butadienes

Masaru Hojo* , Ryōichi Masuda, Etsuji Okada
  • *Department of Industrial Chemistry, Faculty of Engineering, Kobe University, Kobe 657, Japan
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Publication Date:
17 September 2002 (online)

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Ring cleavage of 2-ethoxy-4-isobutoxy-5-trifluoroacetyl-6-trifluoromethyl-3, 4-dihydro-2H-pyran (1) with various secondary amines gives 1-amino-4, 4-bis(trifluoroacetyl)-1,3-butadienes 2a-f in excellent yields. Deacylation of compounds 2a-d by hydrochloric acid gives the corresponding monoacyl derivatives 3a-d in fair yields.