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Synthesis 1990; 1990(5): 389-391
DOI: 10.1055/s-1990-26883
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Synthesis of Pyrroles via Ethyl N-(3-Oxo-1-alkenyl)glycinates

Hermann K. Hombrecher* , Gaby Horter
  • *Institut für Chemie der Medizinischen Universität zu Lübeck, Ratzeburger Allee 160, D-2400 Lübeck 1, Federal Republic of Germany
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Publication Date:
17 September 2002 (online)

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The reaction of ethyl glycinate hydrochloride (1) with 1,3-dicarbonyl compounds 2a-g in presence of triethylamine leads to the formation of ethyl N-(3-oxo-1-alkenyl)glycinates 3a-g. These compounds are easily converted to the pyrroles 4a-g by base-catalyzed intramolecular Knoevenagel condensation.