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Synthesis 1990; 1990(4): 360-365
DOI: 10.1055/s-1990-26878
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5-Amino-4-trifluormethylthiazole und 5-Aminomethyl-4-trifluormethyl-1,3-azole: Nützliche Ausgangssubstanzen für Wirkstoff-Synthesen

Klaus Burger* , Eva Höß, Klaus Geith
  • *Institut für Organische Chemie der Technischen Universität München, Lichtenbergstraße 4, D-8046 Garching bei München, Federal Republic of Germany
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Publikationsdatum:
17. September 2002 (online)

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5-Amino-4-trifluoromethylthiazoles and 5-Aminomethyl-4-trifluoromethyl-1,3-azoles: Useful Starting Materials for the Synthesis of Biologically Active Compounds The title compounds are obtained from 5-fluoro-4-trifluoromethyl-1,3-azoles. Introduction of various side chains of potential biological interest at C-5 can be achieved with electrophiles by reaction of the amino group.

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