Synlett 1990; 1990(9): 537-539
DOI: 10.1055/s-1990-21991
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Reductive Amination of Aldehydes and Ketones with Weakly Basic Anilines Using Sodium Triacetoxyborohydride

Ahmed F. Abdel-Magid* , Cynthia A. Maryanoff
  • *R. W. Johnson Pharmaceutical Research Institute, Department of Chemical Development, Spring House, Pennsylvania 19477, USA
Further Information

Publication History

Publication Date:
08 March 2002 (online)

The weakly basic chloro-, nitro-, cyano-, ethoxy- carbonyl- and carboxy-substituted anilines react with aldehydes and ketones under reductive amination conditions, employing sodium triacetoxyborohydride, to give excellent yields of the corresponding secondary aromatic amines.