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Synlett 1990; 1990(4): 227-228
DOI: 10.1055/s-1990-21045
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Anhydrous Molecular Formaldehyde Solution as a Synthetic Reagent

L. Rodriguez* , N. Lu, N-L. Yang
  • *City University of New York, at The College of Staten Island, Staten Island, NY 10301, USA
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Publication Date:
08 March 2002 (online)

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Stable anhydrous molecular formaldehyde solutions of controlled concentration (0.5M to 3.0M) in tetrahydrofuran have been prepared as an efficient synthetic reagent for hydroxymethylation. This solution has been demonstrated to be a superior reagent for the addition of one carbon to metalated alkylpyridazines in the first synthesis of 4-(ß-hydroxyethyl)-pyridazine and an improved synthesis of 3-(ß-hydroxyethyl)-pyridazine.

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