Synthesis 1989; 1989(11): 856-858
DOI: 10.1055/s-1989-27410
communication
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Simple Three-Step Synthesis of (R)- and (S)-4-Amino-3-hydroxybutanoic Acid (GABOB) by Stereoselective Aldol Addition

Manfred Braun* , Delia Waldmüller
  • *Institut für Organische Chemie und Makromolekulare Chemie der Universität Düsseldorf, Universitätsstraße 1, D-4000 Düsseldorf 1, Federal Republic of Germany
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
02. Mai 2002 (online)

A simple synthesis of both (R)- and (S)-GABOB (5) is reported. In the key step, doubly deprotonated (R)- or (S)-2-Hydroxy-1,2,2-triphenylethyl acetate (HYTRA) (1) is added to Cbz-protected glycinal (2).