RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000084.xml
Synthesis 1989; 1989(11): 818-820
DOI: 10.1055/s-1989-27400
DOI: 10.1055/s-1989-27400
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Enantioselective Synthesis of (-)-(7aS)-2,3,7,7a-Tetrahydro-7a- phenylthio-1H-indene-1,5(6H)-dione and (+)-(8aS)-3,4,8,8a-Tetrahydro-8a-phenylthio-1,6(2H,7H)-naphthalenedione
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
02. Mai 2002 (online)
![](https://www.thieme-connect.de/media/synthesis/198911/lookinside/thumbnails/10.1055-s-1989-27400-1.jpg)
Application of the Hajos-Parrish asymetrically biased aldol condensation to 2-(3-oxobutyl)-2-phenylthio-1,3-cyclopentanedione (5a) or 2-(3-oxobutyl) -2-phenylthio-1,3-cyclohexanedione (5b) using (R)-(+)-proline provided (-)-(7aS)-2,3,7,7a-tetrahydro-7a-phenylthio-1H-indene -1,5(6H)-dione (7a) and (+)-(8aS)-3,4,8,8a-tetrahydro-8a -phenylthio-1,6(2H,7H)-naphthalenedione (7b), respectively, in ≥ 95% enantiomeric excess, as determined by 1H-NMR analysis using tris[3-heptafluoropropylhydroxymethylene)-(+)-camphorato]europium(III).