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Synthesis 1989; 1989(10): 747-751
DOI: 10.1055/s-1989-27381
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A General Method for the Preparation of ß-Aminoesters

Alan R. Katritzky* , Konstantina Yannakopoulou
  • *Department of Chemistry, University of Florida, Gainesville, FL 32611, USA
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Publikationsdatum:
02. Mai 2002 (online)

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3-Dialkylamino (3) and 3-benzyloxycarbonylamino (6) esters are prepared by the Reformatsky reaction of 1-dialkylamino-(1) and 1-benzyloxycarbonylamino-(5) 1-(1-benzotriazolyl)alkanes with ethyl 2-bromoalkanoates. Compounds 1 and 5 are obtained by the condensation of benzotriazole, an aldehyde, and a secondary amine or benzyl carbamate. The procedure can be performed by as a one-pot reaction from benzotriazole.