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Synthesis 1989; 1989(10): 743-745
DOI: 10.1055/s-1989-27379
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Enantioselective Catalysis, Part 481: Highly Enantioselective Catalytic Transfer-Hydrogenation of Itaconic Acid with Formates

Henri Brunner* , Elisabeth Graf, Walter Leitner, Konrad Wutz
  • *Institut für Anorganische Chemie der Universität, Universitätsstraße 31, D-8400 Regensburg, F.R.G.
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Publication Date:
02 May 2002 (online)

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Enantioselective catalytic transfer-hydrogenation of itaconic acid (1) yields optically pure (S)-methylsuccinic acid (2). The hydrogen source is a mixture of formic acid and an amine in the mole ratio of 5:2. The catalyst system constists of a Rh(I), Rh(II), or Rh(III) complex and the chiral phosphane bppm 6. The optical purity exceeds that achieved with Rh(I)/bppm catalysts using gaseous hydrogen.