Download PDF
Synthesis 1989; 1989(9): 719-720
DOI: 10.1055/s-1989-27374
communication
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Convenient Synthesis of 5-Cyano-6-dialkylamino-2-hydroxy-3-methoxycarbonyl-2-methyl-4-(2- or 4-nitrophenyl)-1,2,3,4-tetrahydropyridines and their Dehydration to 5-Cyano-6-dialkylamino-3-methoxycarbonyl-2-methyl-4-(2- or 4-nitrophenyl)-1,4-dihydropyridines

France Laure* , Jean-Claude Pascal
  • *Department of Chemistry, Recherche Syntex France, BP 40, F-91310 Montlhéry, France
Further Information

Publication History

Publication Date:
17 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

The reaction of cyanoacetamidines with methyl 2-[(nitrophenyl)methylene]-3-oxobutanoates leads to 2-hydroxy-1,2,3,4-tetrahydropyridines in high yields. These compounds can be dehydrated to 1,4-dihydropyridines by heating in benzene containing a catalytic amount of p toluenesulfonic acid.