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Synthesis 1989; 1989(7): 542-544
DOI: 10.1055/s-1989-27311
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A Convenient Differential Protection Strategy for Functional Group Manipulation of Aspartic and Glutamic Acids

John M. Scholtz* , Paul A. Bartlett
  • *Department of Chemistry, University of California, Berkeley, CA 94720, USA
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Publication History

Publication Date:
17 September 2002 (online)

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Procedures are provided for selective protection of the α-carboxyl groups of aspartic and glutamic acids via the 5-oxazolidinones 2. A convenient synthesis of a differentially protected derivative of (S)-2,3-diaminopropanoic acid, 3, is described, along with examples of selective manipulation of the γ-carboxyl group of glutamic acid.

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