Synthesis 1989; 1989(6): 423-425
DOI: 10.1055/s-1989-27272
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A New Convenient Method for the Synthesis of Symmetrical and Unsymmetrical N,N′-Disubstituted Ureas

Jan lzdebski* , Danuta Pawlak
  • *Department of Chemistry, University of Warsaw, 1 Pasteur St., PL-02-093 Warsaw, Poland
Further Information

Publication History

Publication Date:
17 September 2002 (online)

A new method is described for the preparation of symmetrically and unsymmetrically disubstituted ureas by aminolysis of bis(4-nitrophenyl) carbonate. The second substitution is slower than the first one, and it is possible to isolate monosubstituted intermediates when equimolar amounts of substrates are used, The reaction of the intermediates with different amines gives unsymmetrical derivatives of urea.