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Synthesis 1989; 1989(2): 135-137
DOI: 10.1055/s-1989-27176
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Synthesis of (±)-erythro- and (±)-threo-1,2-Diphenyltaurines by Diastereoselective Hydrolysis of Thiazetidine 1,1-Dioxides

Evelyne Grunder* , Gérard Leclerc
  • *Laboratoire de Pharmacologie cardiovasculaire et rénale, URA 100 CNRS, Université Louis Pasteur, 11 rue Humann, F-67000 Strasbourg, France
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Publication Date:
17 September 2002 (online)

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The disubstituted analogs of taurine, (±)-erythro- and (±)-threo-2-amino-1,2-diphenyl-ethanesulfonic acids were prepared from (±)-cis- and (±)-trans-2-benzyl-3,4-diphenyl-1,2-thiazetidine 1,1-dioxides, respectively, by diastereoselective hydrolysis of the sulfonamide bond, followed by N-debenzylation.