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Synthesis 1989; 1989(1): 66-69
DOI: 10.1055/s-1989-27156
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The Chemistry of N-Substituted Benzotriazoles; Part II.1 The Preparation of Tertiary Amines Containing Tertiary-Alkyl Groups from Ketones, Secondary Amines, and Organometallic Reagents

Alan R. Katritzky* , Zbigniew Najzarek, Zofia Dega-Szafran
  • *Department of Chemistry, University of Florida, Gainesville, FL 32611, USA
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Publication Date:
27 September 2002 (online)

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The preparation of important pharmaceutically active highly branched tertiary amines by the reaction of Grignard reagents with adducts of cyclic ketones, benzotriazole (or pyrazole) and secondary amines is far superior to previously available routes.